However, significant heterogeneities and instability of the pooled results were detected. The meta-analysis revealed that the pooled difference in mean (DM) was 0.33, 0.76 and 0.43 for AMD within 1 month, AMD within 2 months and AMD within 3 months, respectively. Finally, five studies were included in this meta-analysis. Meta-analyses were performed in Comprehensive Meta-Analysis Version 2.2.064 (Biostat, Englewood, NJ, USA). Outcome of interest in this meta-analysis was accumulative moved distance (AMD). Article screening, data extraction, assessment of risk of bias and evaluation of evidence quality through GRADE were conducted independently and in duplicate by two reviewer authors. PubMed, Web of Knowledge, Embase, CENTRAL, ProQuest Dissertations &Theses, and SIGLE were electronically searched from Jan 1990 to Jun 2013. The aim of this meta-analysis was to critically appraise current evidence and to determine the effectiveness of low-level laser therapy in accelerating orthodontic tooth movement. Abstract: Low-level laser therapy is claimed to accelerate bone remodeling.